Mesh implants are widely utilized in hernia repair surgeries, but postoperative complications present a significant concern. This study analyzes patient reports from the Manufacturer and User Facility Device Experience (MAUDE) database spanning 2000 to 2021 to investigate the emotional aspects of patients following mesh implantation using Natural Language Processing (NLP). Employing the National Research Council Canada (NRC) Emotion Lexicon and TextBlob for sentiment analysis, the research categorizes patient narratives into eight emotions (anger, fear, anticipation, trust, surprise, sadness, joy, and disgust) and assesses sentiment polarity. The goal is to discern patterns in patient sentiment over time and to identify reports signaling urgent concerns, referred to as "Concern Reports," thereby understanding shifts in patient experiences in relation to changes in medical device regulation and technological advancements in healthcare. The study detected an increase in Concern Reports and higher emotional intensity during the periods of 2011-2012 and 2017-2018. Through temporal analysis of Concern Reports and overall sentiment, this research provides valuable insights for healthcare practitioners, enhancing their understanding of patient experiences post-surgery, which is critical for improving preoperative counselling, postoperative care, and preparing patients for mesh implant surgeries. The study underscores the importance of emotional considerations in medical practices and the potential for sentiment analysis to inform and enhance patient care.

In this work, we reflect on the data-driven modeling paradigm that is gaining ground in AI-driven automation of patient care. We argue that the repurposing of existing real-world patient datasets for machine learning may not always represent an optimal approach to model development as it could lead to undesirable outcomes in patient care. We reflect on the history of data analysis to explain how the data-driven paradigm rose to popularity, and we envision ways in which systems thinking and clinical domain theory could complement the existing model development approaches in reaching human-centric outcomes. We call for a purpose-driven machine learning paradigm that is grounded in clinical theory and the sociotechnical realities of real-world operational contexts. We argue that understanding the utility of existing patient datasets requires looking in two directions: upstream towards the data generation, and downstream towards the automation objectives. This purpose-driven perspective to AI system development opens up new methodological opportunities and holds promise for AI automation of patient care.

Lanea George pulls open a steel security door and enters a windowless room where a video camera stares at what looks like a commercial-grade refrigerator. The machine, dubbed Bodhi, whirrs and spins before spitting out seven small plastic bottles containing precisely 70ml of methadone, a bright pink liquid resembling cherry cough syrup. It is used as a substitute for morphine or heroin in addiction treatment. She scoops the bottles off the tray, bundles them with a rubber band and sets them on a shelf. It's not yet 10am and George, the nurse manager at Man Alive, an opioid treatment program – known colloquially as a methadone clinic – in Baltimore, has already finished prepping the doses for the 100 or so patients who will arrive the next day.

With U.S. healthcare spending approaching $5T (NHE Fact Sheet 2024), and 25% of it estimated to be wasteful (Waste in the US the health care system: estimated costs and potential for savings, n.d.), the need to better predict risk and optimal patient care is evermore important. This paper introduces the Large Medical Model (LMM), a generative pre-trained transformer (GPT) designed to guide and predict the broad facets of patient care and healthcare administration. The model is trained on medical event sequences from over 140M longitudinal patient claims records with a specialized vocabulary built from medical terminology systems and demonstrates a superior capability to forecast healthcare costs and identify potential risk factors. Through experimentation and validation, we showcase the LMM's proficiency in not only in cost and risk predictions, but also in discerning intricate patterns within complex medical conditions and an ability to identify novel relationships in patient care. The LMM is able to improve both cost prediction by 14.1% over the best commercial models and chronic conditions prediction by 1.9% over the best transformer models in research predicting a broad set of conditions. The LMM is a substantial advancement in healthcare analytics, offering the potential to significantly enhance risk assessment, cost management, and personalized medicine.

This study applies Natural Language Processing techniques, including Latent Dirichlet Allocation, to analyse anonymised maternity incident investigation reports from the Healthcare Safety Investigation Branch. The reports underwent preprocessing, annotation using the Safety Intelligence Research taxonomy, and topic modelling to uncover prevalent topics and detect differences in maternity care across ethnic groups. A combination of offline and online methods was utilised to ensure data protection whilst enabling advanced analysis, with offline processing for sensitive data and online processing for non-sensitive data using the `Claude 3 Opus' language model. Interactive topic analysis and semantic network visualisation were employed to extract and display thematic topics and visualise semantic relationships among keywords. The analysis revealed disparities in care among different ethnic groups, with distinct focus areas for the Black, Asian, and White British ethnic groups. The study demonstrates the effectiveness of topic modelling and NLP techniques in analysing maternity incident investigation reports and highlighting disparities in care. The findings emphasise the crucial role of advanced data analysis in improving maternity care quality and equity.

Artificial intelligence has dramatically reshaped our interaction with digital technologies, ushering in an era where advancements in AI algorithms and Large Language Models (LLMs) have natural language processing (NLP) systems like ChatGPT. This study delves into the impact of cutting-edge LLMs, notably OpenAI's ChatGPT, on medical diagnostics, with a keen focus on the dental sector. Leveraging publicly accessible datasets, these models augment the diagnostic capabilities of medical professionals, streamline communication between patients and healthcare providers, and enhance the efficiency of clinical procedures. The advent of ChatGPT-4 is poised to make substantial inroads into dental practices, especially in the realm of oral surgery. This paper sheds light on the current landscape and explores potential future research directions in the burgeoning field of LLMs, offering valuable insights for both practitioners and developers. Furthermore, it critically assesses the broad implications and challenges within various sectors, including academia and healthcare, thus mapping out an overview of AI's role in transforming dental diagnostics for enhanced patient care.

Medical documentation, including discharge notes, is crucial for ensuring patient care quality, continuity, and effective medical communication. However, the manual creation of these documents is not only time-consuming but also prone to inconsistencies and potential errors. The automation of this documentation process using artificial intelligence (AI) represents a promising area of innovation in healthcare. This study directly addresses the inefficiencies and inaccuracies in creating discharge notes manually, particularly for cardiac patients, by employing AI techniques, specifically large language model (LLM). Utilizing a substantial dataset from a cardiology center, encompassing wide-ranging medical records and physician assessments, our research evaluates the capability of LLM to enhance the documentation process. Among the various models assessed, Mistral-7B distinguished itself by accurately generating discharge notes that significantly improve both documentation efficiency and the continuity of care for patients. These notes underwent rigorous qualitative evaluation by medical expert, receiving high marks for their clinical relevance, completeness, readability, and contribution to informed decision-making and care planning. Coupled with quantitative analyses, these results confirm Mistral-7B's efficacy in distilling complex medical information into concise, coherent summaries. Overall, our findings illuminate the considerable promise of specialized LLM, such as Mistral-7B, in refining healthcare documentation workflows and advancing patient care. This study lays the groundwork for further integrating advanced AI technologies in healthcare, demonstrating their potential to revolutionize patient documentation and support better care outcomes.

This paper explores the evolving relationship between clinician trust in LLMs, the transformation of data sources from predominantly human-generated to AI-generated content, and the subsequent impact on the precision of LLMs and clinician competence. One of the primary concerns identified is the potential feedback loop that arises as LLMs become more reliant on their outputs for learning, which may lead to a degradation in output quality and a reduction in clinician skills due to decreased engagement with fundamental diagnostic processes. While theoretical at this stage, this feedback loop poses a significant challenge as the integration of LLMs in healthcare deepens, emphasizing the need for proactive dialogue and strategic measures to ensure the safe and effective use of LLM technology. A key takeaway from our investigation is the critical role of user expertise and the necessity for a discerning approach to trusting and validating LLM outputs. The paper highlights how expert users, particularly clinicians, can leverage LLMs to enhance productivity by offloading routine tasks while maintaining a critical oversight to identify and correct potential inaccuracies in AI-generated content. This balance of trust and skepticism is vital for ensuring that LLMs augment rather than undermine the quality of patient care. Moreover, we delve into the potential risks associated with LLMs' self-referential learning loops and the deskilling of healthcare professionals. The risk of LLMs operating within an echo chamber, where AI-generated content feeds into the learning algorithms, threatens the diversity and quality of the data pool, potentially entrenching biases and reducing the efficacy of LLMs.

Healthcare data is a valuable resource for research, analysis, and decision-making in the medical field. However, healthcare data is often fragmented and distributed across various sources, making it challenging to combine and analyze effectively. Record linkage, also known as data matching, is a crucial step in integrating and cleaning healthcare data to ensure data quality and accuracy. Apache Spark, a powerful open-source distributed big data processing framework, provides a robust platform for performing record linkage tasks with the aid of its machine learning library. In this study, we developed a new distributed data-matching model based on the Apache Spark Machine Learning library. To ensure the correct functioning of our model, the validation phase has been performed on the training data. The main challenge is data imbalance because a large amount of data is labeled false, and a small number of records are labeled true. By utilizing SVM and Regression algorithms, our results demonstrate that research data was neither over-fitted nor under-fitted, and this shows that our distributed model works well on the data.

Patient-Centric Knowledge Graphs (PCKGs) represent an important shift in healthcare that focuses on individualized patient care by mapping the patient's health information in a holistic and multi-dimensional way. PCKGs integrate various types of health data to provide healthcare professionals with a comprehensive understanding of a patient's health, enabling more personalized and effective care. This literature review explores the methodologies, challenges, and opportunities associated with PCKGs, focusing on their role in integrating disparate healthcare data and enhancing patient care through a unified health perspective. In addition, this review also discusses the complexities of PCKG development, including ontology design, data integration techniques, knowledge extraction, and structured representation of knowledge. It highlights advanced techniques such as reasoning, semantic search, and inference mechanisms essential in constructing and evaluating PCKGs for actionable healthcare insights. We further explore the practical applications of PCKGs in personalized medicine, emphasizing their significance in improving disease prediction and formulating effective treatment plans. Overall, this review provides a foundational perspective on the current state-of-the-art and best practices of PCKGs, guiding future research and applications in this dynamic field.